CD270 (HVEM), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD270 (HVEM), Human |
| Clone | REA247 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD270 (HVEM) Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA247 recognizes CD270, which is also known as HVEM and derives its name based on the ability of types 1 and 2 herpesvirus gD to bind to it for entry into the cell. CD270 is a type 1 transmembrane protein with a predicted molecular weight of 30 kDa and is a member of the TNFR superfamily. CD270 transmits both activating and inhibitory signals for, e.g., interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells. Expression of CD270 is widely distributed and is found on hematopoietic cells such as dendritic cells, Tregs, monocytes, neutrophils, NK cells, B cells, and T cells, as well as on non-hematopoietic cells. | Additional information: Clone REA247 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2 |
| Gene, Accession # | Gene ID: 8764 |
| Catalog # | 130-127-608 |
| Price | $315 |
| Order / More Info | CD270 (HVEM), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ware, C. F. et al. (2009) Targeting the LIGHT-HVEM pathway. Adv. Exp. Med. Biol. 647: 146-155. | Pasero, C. et al. (2012) The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy. Curr. Opin. Pharmacol. 12 (4): 478-485. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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