Nanog, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Nanog, Mouse |
| Clone | REA297 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Nanog Antibody, anti-mouse, APC, REAfinity™. Clone REA297 recognizes the murine Nanog antigen, a homeobox transcription factor also known as ES cell-associated protein 4. Nanog is thought to be a key factor in maintaining pluripotency. It is expressed in the central portion of the morula, the inner cell mass of the blastocyst, in embryonic stem cells (ESC) and embryonic germ cells (EGC). The expression decreases with ESC differentiation. Nanog is thought to function in concert with other factors such as Oct-4 and SOX2 to establish ESC identity. Overexpression of Nanog in mouse ESC causes them to self-renew in the absence of Leukemia inhibitory factor. Loss of Nanog function causes differentiation of mouse ESC into other cell types. | Additional information: Clone REA297 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | ENK, ecat4, Early embryo specific expression NK-type homeobox protein |
| Gene, Accession # | Gene ID: 71950 |
| Catalog # | 130-104-529 |
| Price | $59 |
| Order / More Info | Nanog, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Mitsui, K. et al. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113: 631-642. | Lin, T. et al. (2005) p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat. Cell Biol. 7 (2): 165-171. | Yates, A. et al. (2005) The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells. Biochem. Soc. Trans. 33 (6): 1518-1521. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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