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Antigenic Specificity | TCR Vα3.2 (b, c), Mouse |
Clone | REA395 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | fluorescein (FITC) conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TCR Vα3.2 (b, c) Antibody, anti-mouse, FITC, REAfinity™. Clone REA395 recognizes the mouse Vα 3.2 T cell receptor (TCR Vα3.2) of mice having the b (e.g., C57BL/6) and c (e.g., SJL, NOD) haplotypes, but not with the strains having the a (Balb/c) or d (DBA/2) haplotype. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Vα elements are expressed preferentially in CD4 or CD8 subsets in a manner that is largely independent of the MHC haplotype. It is likely that the Vα elements interact preferentially with conserved regions of class I or class II molecules. | Additional information: Clone REA395 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | TCRA, TCR Va3.2, TCR-Va3.2 |
Gene, Accession # | Gene ID: 21473 |
Catalog # | 130-106-003 |
Price | $48 |
Order / More Info | TCR Vα3.2 (b, c), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Sim, B. C. et al. (1997) V alpha 3.2 selection in MHC class I mutant mice: evidence for an alternate orientation of TCR-MHC class I interaction. J Immunol 159 (7): 3322-3329. | Pereira, P. et al. (1997) The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci. Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5761-5766. | von Essen, M. R. et al. (2012) Mechanisms behind functional avidity maturation in T cells. Clin. Dev. Immunol. 2012: 163453. |