CD248 (Endosialin), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD248 (Endosialin), Human |
| Clone | REAL1302 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD248 (Endosialin) Antibody, anti-human, PE, REAdye_lease™. Clone REAL1302 is an antibody fragment derived from the full CD248 (Endosialin) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1302 recognizes the human CD248 (Endosialin) antigen, also known as Tumor endothelial marker 1 (TEM1) or CD164 sialomucin-like 1 (CD164L1). CD248 is a single-pass type I transmembrane glycoptrotein belonging to the Group XIV, a novel family of C-type lectin transmembrane receptors. CD248 is expressed on tumor endothelial cells, in metastatic lesions of the liver pericytes and on stromal fibroblasts. CD248 is suggested to be involved in tumor angiogenesis,development and growth and in lymphoid tissue organization. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | Tumor endothelial marker 1, CD164L1, CD164 sialomucin-like 1, TEM1 |
| Gene, Accession # | n/a |
| Catalog # | 130-130-353 |
| Price | $511 |
| Order / More Info | CD248 (Endosialin), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Rettig, W. J. (1992) Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. Proc. Natl. Acad. Sci. U.S.A. 89 (22): 10832-10836. | MacFadyen, J. R. et al. (2005) Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett. 579 (12): 2569-2575. | Simonavicius, N. et al. (2008) Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma. Mod Pathol 21 (3): 308-315. | Viski, C. et al. (2016) Endosialin-Expressing Pericytes Promote Metastatic Dissemination. Cancer Res. 76 (18): 5313-5325. | Khan, K. A. et al. (2019) C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation. FEBS J. 286 (17): 3299-3332. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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