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Antigenic Specificity | TCR Vβ17, Human |
Clone | REA915 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TCR Vβ17 Antibody, anti-human, PE, REAfinity™. Clone REA915 recognizes the human variable β 17 subunit of the αβ T cell receptor (TCR Vβ17). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ17 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell-mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell-mediated immunity and underpins MHC restriction. | Additional information: Clone REA915 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | TCR Vbeta17, TCR Vb17 |
Gene, Accession # | Gene ID: 28570 |
Catalog # | 130-115-248 |
Price | $315 |
Order / More Info | TCR Vβ17, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Kimuram, N. et al. (1987) Sequences and repertoire of the human T cell receptor alpha and beta chain variable region genes in thymocytes. Eur. J. Immunol. 17 (3): 375-383. | Wei, S. et al. (1994) The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40 (1): 27-36. |