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Antigenic Specificity | CD11c, Human |
Clone | REA618 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | Vio Bright B515 conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD11c Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA618 recognizes the human CD11c antigen, a 145-150 kDa type I transmembrane glycoprotein, which is also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells. On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)+ CD123low MDC1s) and low on type 2 myeloid dendritic cells (CD1c (BDCA-1)- CD123- MDC2s). CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. | Additional information: Clone REA618 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | 95, CR4, integrin αX, ITGAX, p150 |
Gene, Accession # | Gene ID: 3687 |
Catalog # | 130-126-883 |
Price | $460 |
Order / More Info | CD11c, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Dzionek, A. et al. (2000) BDCA-2, BDCA-3, BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol 165: 6037-6046. | Bendiss-Vermare, N. et al. (2001) Human thymus contains IFN-alpha-producing CD11c-, myeloid CD11c+, and mature interdigitating dendritic cells. J. Clin. Invest. 107: 835-844. | Barclay, A. N. et al. (1997) In: The Leukocyte Antigen Facts Book, Academic Press, San Diego, CA. (2nd edition): 161-162. |