CD16b, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD16b, Human |
| Clone | REA589 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD16b Antibody, anti-human, FITC, REAfinity™. Clone REA589 recognizes the human CD16b antigen, a glycosylphosphatidylinositol-anchored protein known as low affinity immunoglobulin gamma Fc region receptor III-B. CD16 is expressed in two different isoforms, FcγRIIIa (CD16a), which is found on human NK cells, macrophages, and mast cells, and FcγRIIIb (CD16b) Fc receptors, that bind to the Fc portion of IgG antibodies which mediates NK cell activating. CD16b is polymorphic and has two codominant alleles that are related to Neutrophil Antigen 1 (NA1) and Neutrophil Antigen 2 (NA2). Clone REA589 is present on polymorphonuclear leukocytes (neutrophils) expressing the NA1 molecule. | Additional information: Clone REA589 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | FCGR3B, Fc-gamma RIIIb, FCG3, FCGR3, FcR-10, FcRIII, FcRIIIb |
| Gene, Accession # | Gene ID: 2215 |
| Catalog # | 130-126-529 |
| Price | $270 |
| Order / More Info | CD16b, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ravetch, J. V. et al. (1989) Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J. Exp. Med. 170 (2): 481-497. | Peltz, G. A. et al. (1989) Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG. Proc. Natl. Acad. Sci. U.S.A. 86 (3): 1013-1017. | Gessner, J. E. et al. (1995) The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. J. Biol. Chem. 270 (3): 1350-1361. | Monti, M. et al. (2017) Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells. PLoS One 12 (2): . |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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