TIGIT, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TIGIT, Human |
| Clone | 4E1.2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG3κ |
| Format | biotin conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TIGIT Antibody, anti-human, Biotin. Clone 4E1.2 reacts with a protein containing an immunoglobulin variable (IgV) domain, a transmembrane domain, and an immunoreceptor tyrosine-based inhibitory motif (ITIM), which is called TIGIT (T cell immunoglobulin and ITIM domain). It is expressed on T cells, including Treg cells and memory subsets, as well as on NK cells. The poliovirus receptor (PVR; also called NECL5 or CD155) is a high-affinity coreceptor for TIGIT that is highly expressed on dendritic cells (DCs), fibroblasts, endothelial cells, and some tumor cells. The interaction of TIGIT with PVR on DCs leads to the down-regulation of pro-inflammatory cytokine secretion and the induction of IL-10 production in DCs, exerting an inhibitory effect on T cell activation. |
| Immunogen | n/a |
| Other Names | VSIG9, Vstm3, WUCAM |
| Gene, Accession # | Gene ID: 201633 |
| Catalog # | 130-096-382 |
| Price | $275 |
| Order / More Info | TIGIT, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yu, X. et al. (2008) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 10: 48-57. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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