GITRL, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | GITRL, Human |
| Clone | REA841 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GITRL Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA841 recognizes the human GITRL, also known as the ligand for GITR (glucocorticoid-induced TNF receptor superfamily-related protein) and also called AITR (activation-inducible TNF receptor superfamily-related protein). GITRL, a type II membrane protein and a member of the TNF superfamily, is highly expressed in small intestine, ovary, testis, kidney, and endothelial cells. GITRL is not found in resting or stimulated T cells, B cells, or peripheral blood mononuclear cells (PBMCs). After stimulation by bacterial lipopolysaccharides (LPS), GITRL is upregulated. GITR and GITRL might play an important role for interactions between activated T lymphocytes and endothelial cells. Furthermore, overexpression on monocyte-derived DC enhances their capacity to induce antigen-specific T cell responses. | Additional information: Clone REA841 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | hGITRL, GITR Ligand, GITR-L, AITR Ligand, AITRL, AITR-L, TL6, TNFSF18 |
| Gene, Accession # | Gene ID: 8995 |
| Catalog # | 130-112-975 |
| Price | $365 |
| Order / More Info | GITRL, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kwon, B. et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J. Biol. Chem. 274 (10): 6056-6061. | Gurney, A. L. et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215-218. | Shevach, E. M. et al. (2006) The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat. Rev. Immunol. 6 (8): 613-618. | Tuyaerts, S. et al. (2007) Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells. J. Leukoc. Biol. 82 (1): 93-105. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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