CD207 (Langerin), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD207 (Langerin), Human |
| Clone | REA770 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright B515 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD207 (Langerin) Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA770 recognizes the CD207 antigen, a 40 kDa glycosylated type II transmembrane C-type lectin receptor, and the standard marker for human and murine Langerhans cells (LCs). LCs are a subset of dendritic cells (DCs) that reside in epithelia; the best studied example of these antigen-presenting cells are LCs of the epidermis. CD207 is directly involved in antigen capture as well as endocytosis and induces the formation of typical Birbeck granules in immature DCs. | Additional information: Clone REA770 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CLEC4K, Langerin |
| Gene, Accession # | Gene ID: 50489 |
| Catalog # | 130-112-216 |
| Price | $470 |
| Order / More Info | CD207 (Langerin), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Geissmann, F. et al. (1998) Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells. J. Exp. Med. 187 (6): 961-996. | Valladeau, J. et al. (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12 (1): 71-81. | Rozis, G. et al. (2008) Human Langerhans cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands. Immunology 124 (3): 329-338. | Romani, N. et al. (2010) Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol. Rev. 234 (1): 120-141. | Stoitzner, P. et al. (2010) Isolation of skin dendritic cells from mouse and man. Methods Mol. Biol. 595: 235-248. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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