p120 Catenin pS288, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | p120 Catenin pS288, Human |
| Clone | REA498 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate, other |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | p120 Catenin pS288 Antibody, anti-human, FITC, REAfinity™. Clone REA498 recognizes the human p120 catenin antigen phosphorylated at serine 288 (pS288). p120 catenin exists as four isoforms that range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. p120 catenin is a prototypic member of subfamily of armadillo-domain (ARM) proteins. The p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1-7 and is localized at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Phosphorylation of p120 catenin at multiple sites regulates its various functions and it can be phosphorylated by Src and various receptor tyrosine kinases. | Additional information: Clone REA498 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CTNND1, CAS, CTNND, p120cas, p120ctn, p120, p120ctn |
| Gene, Accession # | Gene ID: 1500 |
| Catalog # | 130-108-726 |
| Price | $264 |
| Order / More Info | p120 Catenin pS288, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Alema, S. et al. (2007) p120 catenin and phosphorylation: Mechanisms and traits of an unresolved issue. Biochim. Biophys. Acta 1773 (1): 47-58. | Petrova, Y. et al. (2012) Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Mol. Biol. Cell 23 (11): 2092-2108. | Takahashi, K. et al. (2014) CD148 tyrosine phosphatase promotes cadherin cell adhesion. PLoS One 9 (11): e112753. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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