Edit |   |
---|---|
Antigenic Specificity | PAX-5 (BSAP), Human/Mouse |
Clone | REA140 |
Host Species | Recombinant Human |
Reactive Species | human, mouse |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PAX-5 (BSAP) Antibody, anti-human/mouse, APC, REAfinity™. Clone REA140 recognizes PAX-5, which belongs to the paired box (PAX) gene family of transcription factors. PAX-5 is the only mammalian PAX transcription factor, which is expressed in hematopoietic cells. Within the hematopoietic cells, expression of PAX-5 is limited to cells of the B-lymphocyte lineage and it exerts transcriptional control of B cell commitment, development, and tumorigenesis. PAX-5 contains DNA binding conserved `paired' domain, which consists of an N- and a C-terminal subdomain. Each subregion contains a homeodomain-like helix-turn-helix motif, which binds to a half-site of the PAX-5 recognition sequence. Depending upon the interaction partners, PAX-5 serves either as an activator or repressor of transcription. For instance, Groucho protein family members, by binding to a conserved octapeptide motif of PAX-5, enable PAX-5 to serve as a repressor. | Additional information: Clone REA140 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | ALL3, BSAP, EBB-1, KLP |
Gene, Accession # | Gene ID: 5079, 18507 |
Catalog # | 130-131-892 |
Price | $366 |
Order / More Info | PAX-5 (BSAP), Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Pridans, C. et al. (2008) Identification of Pax5 target genes in early B cell differentiation. J Immunol 180: 1719-1728. | Fazio, G. et al. (2008) PAX5/TEL acts as a transcriptional repressor causing down-modulation of CD19, enhances migration to CXCL12, and confers survival advantage in pre-BI cells. Cancer Res. 68: 181-189. | He, T. et al. (2011) Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity. J. Biol. Chem. 286: 14137-14145. |