CD317 (BST2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD317 (BST2), Human |
| Clone | REA202 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Immunocytochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD317 (BST2) Antibody, anti-human, APC, REAfinity™. Clone REA202 recognizes the CD317 antigen, which is a lipid raft-associated type II transmembrane glycoprotein. CD317 is composed of a short N-terminal cytosolic domain, a transmembrane domain, and a C-terminal glycosyl-phosphatidylinositol anchor. Expression of CD317 is upregulated in the presence of IFN-α on T and B cells, is found on the apical surface of polarized epithelial cells, and on myeloma cells. CD317 expression is also found in an intracellular pool and the protein cycles between this intracellular pool and the cell surface in a clathrin dependent manner. It has been shown to play a role in regulating the growth and development of B cells, cell adhesion, cell migration, and in cultured cells. CD317 restricts the release of formed viral particles at the surface of infected cells. | Additional information: Clone REA202 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | BST2, Tetherin, PDCA1, HM1.24 |
| Gene, Accession # | Gene ID: 684 |
| Catalog # | 130-101-660 |
| Price | $142 |
| Order / More Info | CD317 (BST2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Rollason, R. et al. (2009) A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J. Cell Biol. 184: 721-736. | Habermann, A. et al. (2010) CD317/Tetherin is enriched in the HIV-1 envelope and downregulated from the plasma membrane upon virus infection. J. Virol. 84: 4646-4658. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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