Bcl-2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Bcl-2, Human |
| Clone | REA872 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Bcl-2 Antibody, anti-human, Vio® B515, REAfinity™. Clone REA872 recognizes the human Bcl-2 antigen, which is an intracellular single-pass membrane protein found primarily in the mitochondrion outer membrane, the nucleus membrane, and the endoplasmic reticulum membrane. Bcl-2 is a member of the Bcl-2 family of regulator proteins and it forms homodimers or heterodimers with other Bcl-2 family members. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability and it appears to function in a feedback loop system with caspases. Caspase activity is either inhibited by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. | Additional information: Clone REA872 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | BCL2 |
| Gene, Accession # | Gene ID: 596 |
| Catalog # | 130-130-496 |
| Price | $158 |
| Order / More Info | Bcl-2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Bruey, J. M. et al. (2007) Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell 129 (1): 45-56. | Wei, Y. et al. (2008) JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30 (6): 678-688. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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