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Antigenic Specificity | CD49c, Human |
Clone | REA360 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | APC-Vio 770 conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD49c Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA360 recognizes the human CD49c antigen, a single-pass type I membrane protein also known as integrin α-3 (ITGA3) or VLA-3α. CD49c forms a heterodimer with integrin β1 (α3β1, CD49c/CD29, VLA-3) and plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin. It is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. CD49c/CD29 plays a role in cell-cell and cell-matrix adhesion through binding fibronectin, laminin, collagen, epiligrin, thrombospondin, and CSPG4. | Additional information: Clone REA360 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | ITGA3, MSK18, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA-3α |
Gene, Accession # | Gene ID: 3675 |
Catalog # | 130-105-368 |
Price | $360 |
Order / More Info | CD49c, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Carter, W. G. et al. (1991) Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell 65 (4): 599-610. | Takada, Y. et al. (1991) Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J. Cell Biol. 115 (1): 257-266. | de Melker, A. A. et al. (1997) The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. Lab. Invest. 76 (4): 547-563. |