CD117, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD117, Human |
| Clone | REA787 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD117 Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA787 recognizes the human CD117 antigen, also known as c-kit or SCF receptor, which is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1-3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β+ T cells, CD19+ B cells, and CD56+ NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts. Clone REA787 recognizes a different epitope than clone AC126 and may interfere with SCF-binding. It is therefore not recommended for indirect cell isolation, but is optimal for flow cytometric analysis of cells separated with the CD117 MicroBead Kit, human. | Additional information: Clone REA787 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | c-kit, PBT, SCFR, KIT |
| Gene, Accession # | Gene ID: 3815 |
| Catalog # | 130-111-673 |
| Price | $146 |
| Order / More Info | CD117, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Buhring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860. | Kubo, H. et al. (2008) Increased cardiac myocyte progenitors in failing human hearts. Circulation 118: 649-657. | Berglund, E. et al. (2013) Evidence for Ca2+-regulated ATP release in gastrointestinal stromal tumors. Exp. Cell Res. 319 (8): 1229-1238. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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