CD194 (CCR4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD194 (CCR4), Human |
| Clone | REA279 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | purified |
| Size | 100 µg in 100 µL |
| Concentration | n/a |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD194 (CCR4) Antibody, anti-human, pure, REAfinity™. Clone REA279 recognizes the CD194 antigen, a seven-transmembrane G-protein-coupled receptor also known as C-C chemokine receptor type 4 (CCR4). CD194 is expressed on activated T?2 cells, regulatory T cells, a subset of B cells, activated natural killler (NK) cells, basophils, monocytes, NK cells, and platelets. It is expressed at high levels by skin-infiltrating lymphocytes, at lower levels by lung and synovial fluid lymphocytes, but never by intestinal lymphocytes. CD194 is the specific receptor for the chemokines CCL17 (TARC) and CCL22 (MDC). Human peripheral blood regulatory T cells can be divided into two distinct populations based on the expression of CCR4. The majority of freshly isolated regulatory T cells express CD194 and represent memory-type regulatory T cells, while CD194 regulatory T cells require anti-CD3 antibody-mediated activation to acquire a regulatory activity. Depletion of 194+ T cells leads to T?1-type polarization of CD4+ T cells and augmentation of CD8+ T cell responses to tumor antigens. | Additional information: Clone REA279 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CCR4, CC-CKR-4, CKR4, CMKBR4, CHEMR13, K5-5 |
| Gene, Accession # | Gene ID: 1233 |
| Catalog # | 130-122-323 |
| Price | $205 |
| Order / More Info | CD194 (CCR4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Baatar, D. et al. (2007) Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL. J Immunol 178 (8): 4891-4900. | Sallusto, F. et al. (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187 (6): 875-883. | Kunkel, E. J. et al. (2002) Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. Am. J. Pathol. 160 (1): 347-355. | Power, C. A. et al. (1995) Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J. Biol. Chem. 270 (33): 19495-19500. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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