QA-2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | QA-2, Mouse |
| Clone | REA523 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | QA-2 Antibody, anti-mouse, PE, REAfinity™. Clone REA523 recognizes the mouse Qa-2 antigen, a 40 kDa single-pass type I membrane protein, which is also known as H-2 class I histocompatibility antigen Q7 alpha chain (H2-Q7). Qa-2 is a murine non-classical MHC class I molecule involved in the modulation of immune responses by interacting with T CD8+ and NK cell inhibitory receptors. The murine Qa-2 genes map to the H-2Q region, between the classical class I H-2D locus and the H-2TL cluster of class lb sequences. This locus encodes a variable number of class Ib genes in different strains. Strains expressing high (Qa-2high), medium (Qa-2med), low (Qa-2low), and no Qa-2 (Qa-2nul) were identified. Qa-2 is found as membrane-bound and soluble isoforms generated by alternative splicing. It is expressed mostly by lymphoid-derived cells and plays an important role in controlling growth and murine fetal development and, like HLA-G, the molecule is related to the protection of the fetus by inhibiting maternal NK cell-mediated lysis. | Additional information: Clone REA523 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | H2-Qa2, H2-Q7, H2-Q7 |
| Gene, Accession # | Gene ID: 15018, 110558, 15019 |
| Catalog # | 130-107-907 |
| Price | $66 |
| Order / More Info | QA-2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Melo-Lima, B. L. et al. (2014) Differential transcript profiles of MHC class Ib(Qa-1, Qa-2, and Qa-10) and Aire genes during the ontogeny of thymus and other tissues. J Immunol: . | Devlin, J. J. et al. (1985) Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison. EMBO J. 4 (12): 3203-3207. | Lu, N. et al. (2011) Dynamic expression of Qa-2 during acute graft rejection. Mol. Med. 17 (3-4): 248-255. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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