Integrin β5, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityIntegrin β5, Human
CloneREA718
Host SpeciesRecombinant Human
Reactive Specieshuman
IsotypeIgG1
FormatVio Bright FITC conjugate
Size100 tests in 200 µL
Concentration1:50
ApplicationsFlow cytometry
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DescriptionIntegrin β5 Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA718 recognizes the human integrin β5 antigen, a 95 kDa glycoprotein single-pass type I membrane protein. Integrins are a family of transmembrane receptors that mediate adhesion of cells to extracellular matrices, as well as intercellular interactions. These interactions transduce signals that control complex cell functions such as proliferation, differentiation, and survival, and require the regulation of gene expression. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin αV/β5 heterodimer is found on many types of tissue cells, such as epithelial cells, endothelial cells, keratinocytes, and osteoblastic cells. It is a receptor for fibronectin and vitronectin and acts as a receptor for adenovirus type C. | Additional information: Clone REA718 displays negligible binding to Fc receptors.
Immunogenn/a
Other Namesintegrin b5, integrin beta 5, ITGB5
Gene, Accession #Gene ID: 3693
Catalog #130-111-219
Price$395
Order / More InfoIntegrin β5, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesKim, J. P. et al. (1994) Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor. J. Biol. Chem. 269 (43): 26926-26932. | Zhang, H. et al. (2004) Myosin-X provides a motor-based link between integrins and the cytoskeleton. Nat. Cell Biol. 2004 (6): 523-531. | Lyle, C. et al. (2010) Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. J. Virol. 7 (148): 1743-1745.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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