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Antigenic Specificity | CD40, Human |
Clone | HB14 |
Host Species | Mouse |
Reactive Species | human, nonhuman primate |
Isotype | IgG1κ |
Format | biotin conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD40 Antibody, anti-human, Biotin. The HB14 monoclonal antibody reacts with human CD40, a 45-50 kDa type I transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed primarily on B cells, macrophages, dendritic cells, endothelial cells, and fibroblasts and at lower levels on plasma cells and a subset of peripheral T cells. CD40 is involved in B cell differentiation and proliferation, isotype class-switching, and protection of B cells from apoptosis. Interaction of CD40 with its ligand CD154 is important in T cell-B cell interaction and plays a role in co-stimulation and immune regulation. Clone HB14 blocks the binding of CD40 to CD154. |
Immunogen | n/a |
Other Names | Bp50, CDW40, TNFRSF5, p50 |
Gene, Accession # | Gene ID: 958 |
Catalog # | 130-094-142 |
Price | $264 |
Order / More Info | CD40, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Kansas, G. S. et al. (1991) Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinasedependent pathway. J Immunol 147 (12): 4094-4102. | Banchereau, J. et al. (1994) The CD40 antigen and its ligand. Annu. Rev. Immunol. 12: 881-926. |