GARP (LRRC32), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-GARP (LRRC32), Mouse antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | GARP (LRRC32), Mouse |
| Clone | REA139 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GARP (LRRC32) Antibody, anti-mouse, PE, REAfinity™. Clone REA139 recognizes murine GARP, a 80 KDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes and platelets. Activated GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to nonactive TGFβ. Thus, GARP as a latent TGFβ binding protein (LTBP) regulates the surface expression of TGFβ and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGFβ is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells. | Additional information: Clone REA139 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | LRRC32, Garpin, Glycoprotein A repetitions predominant |
| Gene, Accession # | Gene ID: 434215 |
| Catalog # | 130-102-921 |
| Price | $46 |
| Order / More Info | GARP (LRRC32), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Tran, D. Q. et al. (2009) GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450. | Battaglia, M. et al. (2009) The Tregs' world according to GARP. Eur. J. Immunol. 39 (12): 3296-3300. | Vermeersch, E. et al. (2017) The role of platelet and endothelial GARP in thrombosis and hemostasis. PLoS One 12 (13): e0173329. | Wang, R. et al. (2008) Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS One 3 (7): e2705. | Ollendorff, V. et al. (1994) The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ. 5: 213-219. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG
Return to Antibodies