CD208 (DC-LAMP), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD208 (DC-LAMP), Human |
| Clone | REA295 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD208 (DC-LAMP) Antibody, anti-human, PE, REAfinity™. Clone REA295 recognizes the CD208 antigen, a single-pass type I intracellular protein also known as lysosome-associated membrane glycoprotein 3 (LAMP-3) or DC-lysosome-associated membrane glycoprotein (DC-LAMP). CD208 was first cloned as a gene specifically expressed in lung tissues and found to be overexpressed in primary cancers of the esophagus, colon, fallopian tube, ovary, breast, and liver, although its expression was barely detectable in the corresponding normal tissues. It is almost exclusively expressed by mature dendritic cells (DCs). Expression can be induced in CD34+ derived dendritic cells by stimulation with GM-CSF and TNF-α or in monocytes by the stimulation with GM-CSF and IL-4. CD208 is found in the MHC class II compartment immediately before the translocation of MHC class II molecules to the cell surface, after which it concentrates into perinuclear lysosomes. This suggests that CD208 might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of DC. | Additional information: Clone REA295 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | LAMP3, DC LAMP, Protein TSC403 |
| Gene, Accession # | Gene ID: 27074 |
| Catalog # | 130-104-410 |
| Price | $110 |
| Order / More Info | CD208 (DC-LAMP), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | de Saint-Vis, B. et al. (1998) A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity 9 (3): 325-336. | Bell, D. et al. (1999) In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J. Exp. Med. 190 (10): 1417-1426. | Kanao, H. et al. (2005) Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer. Cancer Res. 65 (19): 8640-8645. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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