CD154, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD154, Human |
| Clone | REA238 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | PE-Vio 615 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD154 Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA238 recognizes the human CD154 antigen, a 39 kDa transmembrane glycoprotein, also known as CD40L, gp39, T-BAM, TRAP, or Ly-62, which is a proinflammatory and prothrombotic ligand in the tumor necrosis factor family. CD154 is transiently up-regulated on activated CD4+ T cells and plays an important role as a costimulatory molecule in T cell/antigen-presenting cell interactions through ligation of CD40. It mediates B cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. | Additional information: Clone REA238 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CD40L, CD40-L, gp39, T-BAM, TRAP, Ly-62, HIGM1, IGM |
| Gene, Accession # | Gene ID: 959 |
| Catalog # | 130-123-039 |
| Price | $335 |
| Order / More Info | CD154, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Hollenbaugh, D. et al. (1992) The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J. 11 (12): 4313-4321. | Frentsch, M. et al. (2005) Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med 11: 1118-1124. | Furman, M. et al. (2004) Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. J. Am. Coll. Cardiol. 43 (12): 2319-2325. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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