CD66b, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD66b, Human |
| Clone | REA306 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD66b Antibody, anti-human, APC, REAfinity™. Clone REA306 recognizes the human CD66b antigen, a glycosylphosphatidylinositol (GPI)-linked protein, which is also known as carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8). CD66b is exclusively expressed on neutrophils and eosinophils and on leukocytes of chronic myeloid leukemia patients and bone marrow. Under normal conditions, neutrophils have minimal expression of CD66b, but incubation in vitro with inflammatory agonists rapidly increases this expression. Furthermore, expression of CD66b in eosinophils is enhanced in vivo in patients with a helminth infection, specifically with Schistosoma mansoni. The eosinophil expression of CD66b is also enhanced in vitro by incubation with activated lymphocytes or by brief incubation with interleukin 5 (IL-5). Crosslinking of CD66b on peripheral blood neutrophils mediates the release of IL-8 from intracellular storage. | Additional information: Clone REA306 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CEACAM8, CD67, CGM6, NCA-95 |
| Gene, Accession # | Gene ID: 1088 |
| Catalog # | 130-117-692 |
| Price | $325 |
| Order / More Info | CD66b, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yoon, J. et al. (2007) CD66b regulates adhesion and activation of human eosinophils. J Immunol 179 (12): 8454-8462. | Molgora, M. et al. (2017) IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature 551 (7678): 110-114. | Eades-Perner, A. M. et al. (1998) Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. Blood 91 (2): 663-672. | Berling, B. et al. (1990) Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. Cancer Res. 50 (20): 6534-6539. | Pearl, M. L. et al. (2014) Prognostic analysis of invasive circulating tumor cells (iCTCs) in epithelial ovarian cancer. Gynecol. Oncol. 134 (3): 581-590. | Liakopoulos, V. et al. (2018) Hemodialysis-related changes in phenotypical features of monocytes. Sci Rep 8 (1): 13964. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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