TCR Vβ23, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCR Vβ23, Human |
| Clone | REA497 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright V423 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCR Vβ23 Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA497 recognizes the human variable beta 23 subunit of the αβ T cell receptor (TCR Vβ23). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ23 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell-mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell-mediated immunity and underpins MHC restriction. | Additional information: Clone REA497 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | Gene ID: 28564 |
| Catalog # | 130-131-310 |
| Price | $498 |
| Order / More Info | TCR Vβ23, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Born, W. et al. (1985) Rearrangement of T-cell receptor beta-chain genes during T-cell development. Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2925-2929. | van den Beemd, R. et al. (2000) Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 40 (4): 336-345. | Trautmann, A. et al. (2003) Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation. Immunology 108 (3): 305-312. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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