CrkL pY207, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CrkL pY207, Human |
| Clone | REA500 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CrkL pY207 Antibody, anti-human, PE, REAfinity™. Clone REA500 recognizes the human CrkL antigen phosphorylated at tyrosine 207 (pY207). CRKL is a member of adaptor proteins that participate in signal transduction in response to both extracellular and intracellular stimuli, such as growth factors, cytokines, and the oncogenic BCR-ABL fusion protein. CRKL consists of an N-terminal Src homology 2 (SH2) domain followed by two SH3 domains (SH2-SH3N-SH3C). The SH2 domain of CRKL binds to phosphorylated Y-x-x-P motif present in many docking proteins, such as BCAR1, Paxillin, and GAB, whereas the SH3N domain binds to proline-rich P-x-x-P-x-K motif-containing proteins, such as Son of Sevenless (SOS), RAPGEF1, p85, ABL1, and BCR-ABL. Through these interactions, CRKL facilitates the timely and localized formation of protein complexes required for signal transduction in many biological processes including cell proliferation, survival, adhesion, and migration. CRKL is preferentially expressed in hematopoietic cells. Y207 in CRKL represents the major in vivo phosphorylation site. It is phosphorylated in hematopoietic cells that express the BCR-ABL fusion protein. Phosphorylation of Y207 provides a binding site for the CRKL SH2 domain and potentially for other SH2-containing proteins. | Additional information: Clone REA500 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Crk-like |
| Gene, Accession # | Gene ID: 1399 |
| Catalog # | 130-107-738 |
| Price | $104 |
| Order / More Info | CrkL pY207, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | ten Hoeve, J. et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 16: 5662-5668. | de Jong, R. et al. (1997) Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. Oncogene 14 (5): 507-513. | Park, T. J. et al. (2014) Essential roles of Crk and CrkL in fibroblast structure and motility. Oncogene 33 (43): 5121-5132. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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