CD286 (TLR6), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD286 (TLR6), Human |
| Clone | REA382 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD286 (TLR6) Antibody, anti-human, PE, REAfinity™. Clone REA382 recognizes the human CD286 antigen, a single-pass type I membrane protein also known as toll-like receptor 6 (TLR6). CD286 is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. Toll-like receptors are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various toll-like receptors exhibit different patterns of expression. CD286 is colocalized with TLR2 on the cell surface of monocytes/macrophages, dendritic cells, and granulocytes. It participates in the innate immune response to gram-positive bacteria and fungi and specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. CD286 acts via MYD88 and TRAF6, leading to NFκB activation, cytokine secretio,n and the inflammatory response. | Additional information: Clone REA382 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TLR6 |
| Gene, Accession # | Gene ID: 10333 |
| Catalog # | 130-106-631 |
| Price | $104 |
| Order / More Info | CD286 (TLR6), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Takeuchi, O. et al. (1999) TLR6: A novel member of an expanding toll-like receptor family. Gene 231 (1-2): 59-65. | Buwitt-Beckmann, U. et al. (2006) TLR1- and TLR6-independent recognition of bacterial lipopeptides. J. Biol. Chem. 281 (14): 9049-9057. | Jin, B. et al. (2012) The effects of TLR activation on T-cell development and differentiation. Clin. Dev. Immunol. 2012 (836485): doi: 10.1155/2012/83. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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