IRAK4, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | IRAK4, Human |
| Clone | REA462 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IRAK4 Antibody, anti-human, PE, REAfinity™. Clone REA462 recognizes the human interleukin-1 receptor-associated kinase 4 (IRAK4) antigen, regardless of phosphorylation status. IRAK4 is a serine/threonine-protein kinase, which is also known as renal carcinoma antigen NY-REN-64. Interleukin-1 receptor-associated kinases (IRAKs) are key components in the signal transduction pathways utilized by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R), and toll-like receptors (TLRs). Out of four members in the mammalian IRAK family, IRAK4 is considered to be the ``master IRAK'', the only family member indispensable for IL-1R/TLR signaling. In MyD88-dependent TIR signaling, IRAK4 is the initial receptor-proximal protein kinase that is recruited and activated upon ligation of receptors, and it interacts with multiple, key downstream signaling molecules. Targeted deletion of IRAK4 in mice reveals severe defects in cytokine responses and downstream signaling pathways induced by IL-1R and TLRs. Cells derived from human patients, who are deficient in IRAK4 due to gene deletion/mutations, clearly exhibit impaired responses to IL-1, IL-18, or exogenous MyD88-dependent TLR ligands. Together with its broad impact on TLR and IL-1R signaling, IRAK4 may be a key target for therapeutic intervention in various inflammatory disorders. | Additional information: Clone REA462 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | IPD1, IRAK-4, NY-REN-64, REN64, Q69FE3 |
| Gene, Accession # | Gene ID: 51135 |
| Catalog # | 130-118-472 |
| Price | $121 |
| Order / More Info | IRAK4, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nahid, M. A. et al. (2013) Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J Immunol 190 (3): 1250-1263. | Li, S. et al. (2002) IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5567-5572. | Xiong, N. et al. (2012) CCR10 and its ligands in regulation of epithelial immunity and diseases. Protein Cell 3 (8): 571-580. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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