STAT5a, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | STAT5a, Human |
| Clone | REA549 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | STAT5a Antibody, anti-human, APC, REAfinity™. Clone REA549 recognizes the human STAT5a antigen, a member of signal transducers and activators of the transcription (STAT) family. The seven STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon (IFN)-α, IFN-γ, EGF, PDGF, and interleukin (IL)-6). STAT5a regulates the expression of milk proteins during lactation and mediates cellular responses to the receptor tyrosine-protein kinase ERBB4. It may induce cellular responses to activated FGFR1, FGFR2, FGFR3, and FGFR4. Among others STAT5a is expressed in prostate and breast cancer. | Additional information: Clone REA549 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MGF, STAT5 |
| Gene, Accession # | Gene ID: 6776 |
| Catalog # | 130-127-624 |
| Price | $136 |
| Order / More Info | STAT5a, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Williams, C. C. et al. (2004) The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J. Cell Biol. 167 (3): 469-478. | Lin, J. X. et al. (2000) The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19 (21): 2566-2576. | Aoki, N. et al. (2002) A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol. 16 (1): 58-69. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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