CD86, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD86, Mouse |
| Clone | REA1190 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | Vio Bright R720 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Mass cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD86 Antibody, anti-mouse, Vio® Bright R720, REAfinity™. Clone REA1190 recognizes the mouse CD86 antigen, also known as B7-2, an 80 kDa molecule and a member of the immunoglobulin superfamily. Together with CD80 (B7-1) it belongs to the B7 family of costimulatory molecules. CD86 is expressed on activated antigen-presenting cells, including B cells, dendritic cells, and monocytes/macrophages. The interaction of CD86 with its ligands CD28 and CD152 (CTLA- 4) plays a critical role in induction and regulation of immune responses, e.g., cross-talk between T and B cells, T cell costimulation, or immunoglobulin class-switching. Binding of CD86 to CD28 on T cells results in transduction of costimulatory signals for activation or proliferation of T cells, or cytokine production. In contrast, binding of CD86 to CTLA-4 regulates T cell activation and diminishes the immune response. | Additional information: Clone REA1190 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | B7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2 |
| Gene, Accession # | Gene ID: 12524 |
| Catalog # | 130-128-565 |
| Price | $199 |
| Order / More Info | CD86, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kin, N. W. et al. (2006) CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways. J Immunol 176 (11): 6727-6735. | Nakajima, A. et al. (1997) Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells. Int. Immunol. 9 (5): 637-644. | Zhu, X. Y. et al. (2005) Blockade of CD86 signaling facilitates a T?2 bias at the maternal-fetal interface and expands peripheral CD4+CD25+ regulatory T cells to rescue abortion-prone fetuses. Biol. Reprod. 72 (2): 338-345. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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