B7-H4, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | B7-H4, Mouse |
| Clone | REA392 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | B7-H4 Antibody, anti-mouse, APC, REAfinity™. Clone REA392 recognizes the mouse B7-H4 antigen, a glycosylphosphatidylinositol (GPI) linked protein which is also known as V-set domain containing T-cell activation inhibitor 1 (Vtcn1). The B7 family of T cell costimulatory and coinhibitory molecules plays a pivotal role in the regulation of adaptive immune responses. As such, B7-H4 was identified as a coinhibitory member of the B7 family. In mice, B7-H4 expression is limited to B cells and APCs. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. It has also been shown to negatively regulate neutrophil-mediated innate immune responses. Apart from the immune system, B7-H4 is overexpressed on some tumor cancer cells. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells, in the suppression of tumor-associated antigen-specific T-cell immunity. | Additional information: Clone REA392 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Vtcn1, B7h4, B7S1, B7x, BC032925 |
| Gene, Accession # | Gene ID: 242122 |
| Catalog # | 130-106-340 |
| Price | $93 |
| Order / More Info | B7-H4, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Leung, J. et al. (2013) Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol 190 (12): 6651-6661. | Sica, G. L. et al. (2003) B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18 (6): 849-861. | Zhu, G. et al. (2009) B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood 113 (8): 1759-1767. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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