CD125 (IL-5Rα), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD125 (IL-5Rα), Mouse |
| Clone | REA343 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD125 (IL-5Rα) Antibody, anti-mouse, APC-Vio® 770, REAfinity™. Clone REA343 recognizes the mouse CD125 antigen, a single-pass type I membrane protein, also known as interleukin-5 receptor subunit α (IL-5Rα). The IL-5 receptor is a heterodimer composed of a ligand specific α subunit and a signal transducing β subunit which is shared by the receptors for IL-3, GM-CSF, and IL-5. CD125 is expressed on eosinophils, basophils, and B cells. IL-5 is a conserved hematopoietic cytokine which is mainly produced by T?2 cells after stimulation with antigens, and by mast cells upon stimulation with an allergen/IgE complex or a calcium ionophore. The overexpression of IL-5 in vivo significantly increases the numbers of eosinophils and B cells, while mice lacking the functional gene for IL-5 display various developmental and functional impairments in the B cell and eosinophil lineages. | Additional information: Clone REA343 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CDw125, Il5r, IL-5RA |
| Gene, Accession # | Gene ID: 16192 |
| Catalog # | 130-125-232 |
| Price | $162 |
| Order / More Info | CD125 (IL-5Rα), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Takaki, S. et al. (1990) Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J. 9 (13): 4367-4374 . | Mao, H. et al. (2006) Effect of interleukin-5 receptor-alpha short hairpin RNA-expressing vector on bone marrow eosinophilopoiesis in asthmatic mice. Adv. Ther. 23 (6): 938-956. | Kusano, S. et al. (2012) Structural basis of interleukin-5 dimer recognition by its α receptor. Protein Sci. 21 (6): 850-864. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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