CD107b, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD107b, Mouse |
| Clone | REA1182 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD107b Antibody, anti-mouse, FITC, REAfinity™. Clone REA1182 recognizes the mouse CD107b antigen, a highly glycosylated 110 kDa single-pass type I membrane protein also known as lysosome-associated membrane protein-2 (LAMP-2) or Mac-3 antigen. It is widely located in lysosomal membranes and the plasma membrane of macrophages and some myeloid cell lines. Under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, in malignant carcinoma cells, and in cytotoxic T lymphocytes, it is also found at the cell surface. CD107b has been described as a receptor for the selective import and degradation of cytosolic proteins in the lysosome or chaperone-mediated autophagy. | Additional information: Clone REA1182 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | LAMP-2, Lamp2, LGP-B, Mac-3 |
| Gene, Accession # | Gene ID: 16784 |
| Catalog # | 130-122-103 |
| Price | $54 |
| Order / More Info | CD107b, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Cha, Y. et al. (1990) The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J. Biol. Chem. 265 (9): 5008-5013. | Tanaka, Y. et al. (2000) Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406 (6798): 902-906. | Asaoka, Y. et al. (2013) Immunohistochemistry of LAMP-2 and adipophilin for phospholipidosis in liver and kidney in ketoconazole-treated mice. Exp. Toxicol. Pathol. 65 (6): 817-823. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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