PGP9.5 (UCH-L1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | PGP9.5 (UCH-L1), Human |
| Clone | REAL1239 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PGP9.5 (UCH-L1) Antibody, anti-human, PE, REAdye_lease™. Clone REAL1239 is an antibody fragment derived from the full PGP9.5 (UCH-L1) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1239 recognizes the thiol protease PGP9.5 (UCH-L1), also known as neuron cytoplasmic protein gene product 9.5 and ubiquitin-C-terminal hydrolase 1 protein, that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin, and plays a role in the processing of ubiquitin precursors and ubiquinated proteins. PGP9.5 (UCH-L1) is present in neurons and is a specific marker of the diffuse neuroendocrine system and their tumors. Furthermore, expression of PGP9.5 (UCH-L1) in myeloma cells was found. In Parkinson and Alzheimer diseases, PGP9.5 (UCH-L1) is down-regulated in brains. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | UCHL1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, PGP 9.5, Neuron cytoplasmic protein 9.5, Ubiquitin thioesterase L1 |
| Gene, Accession # | n/a |
| Catalog # | 130-129-894 |
| Price | $510 |
| Order / More Info | PGP9.5 (UCH-L1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Choi, J. et al. (2004) Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J. Biol. Chem. 279 (13): 13256-13264. | Bilguvar, K. et al. (2013) Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration. Proc. Natl. Acad. Sci. U.S.A. 110 (9): 3489-3494. | Otsuki, T. et al. (2004) Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells. Br J Haematol 127 (3): 292-298. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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