CD273 (PD-L2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD273 (PD-L2), Human |
| Clone | REA985 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD273 (PD-L2) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA985 recognizes the human CD273 antigen, also known as B7-DC or PD-L2. CD273 with an approximate molecular weight of 29 kDa is a type I transmembrane protein, belonging to the B7 family of protein ligands and to the Ig superfamily. CD273 is mainly expressed on dendritic cells (DCs) and activated macrophages. It has been shown to interact with programmed-death-receptor 1 (PD-1). A stimulatory as well as a inhibitory role of CD273 in T cell activation has been proposed. | Additional information: Clone REA985 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2 |
| Gene, Accession # | Gene ID: 80380 |
| Catalog # | 130-116-565 |
| Price | $355 |
| Order / More Info | CD273 (PD-L2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Tseng, S. Y. et al. (2001) B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193: 839-846. | Greenwald, R. J. et al. (2005) The B7 family revisited. Annu. Rev. Immunol. 23: 515-548. | Pfistershammer, K. et al. (2006) No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. Eur. J. Immunol. 36 (5): 1104-1113. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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