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Antigenic Specificity | CD309 (VEGFR-2), Human |
Clone | ES8-20E6 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1κ |
Format | PE-Vio 770 conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD309 (VEGFR-2) Antibody, anti-human, PE-Vio® 770. The CD309 antibody recognizes the CD309 antigen, a transmembrane tyrosine kinase, and is also known as vascular endothelial growth factor receptor-2 (VEGFR-2) or kinase insert domain-containing receptor (KDR). CD309 is a high-affinity receptor for VEGF and plays a role in hematopoiesis. It is also involved in angiogenesis, both during embryogenesis and in the context of homeostatic or pathological events, e.g., vascularization of tumors. It has been identified on a subset of hematopoietic stem cells (HSCs), endothelial progenitor cells (EPCs), as well as on their common progenitor, the hemangioblast. CD309 expression is also found on mature endothelial cells (ECs). |
Immunogen | n/a |
Other Names | KDR, Flk1, VEGFR, VEGFR2 |
Gene, Accession # | Gene ID: 3791 |
Catalog # | 130-120-481 |
Price | $360 |
Order / More Info | CD309 (VEGFR-2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Shalaby, F. et al. (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66. | Eichmann, A. et al. (1997) Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2. Proc. Natl. Acad. Sci. U.S.A. 94: 5141-5146. | Flamme, I. et al. (1995) Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo. Dev. Biol. 169: 699-712. | Auerbach, R. et al. (1996) Hematopoietic stem cells in the mouse embryonic yolk sac. Stem Cells 14: 269-280. |