CD172b (SIRPβ), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD172b (SIRPβ), Human |
| Clone | REA1170 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 615 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD172b (SIRPβ) Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA1170 recognizes the human CD172b antigen, a single-pass type I membrane protein also known as signal-regulatory protein beta (SIRPβ). Signal regulatory proteins (SIRPs) are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. SIRPs can be divided into two subfamilies, CD172a and CD172b, based on the putative structures of their C-terminal intracellular domains which distinguish them as either activating (CD172b) or inhibitory (CD172a) isoforms. CD172b is expressed on peripheral blood monocytes, dendritic cells, and granulocytes. | Additional information: Clone REA1170 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Signal-regulatory protein β-1 (SIRP-β-1), SIRP-BETA-1, CD172 antigen-like family member B |
| Gene, Accession # | Gene ID: 10326 |
| Catalog # | 130-120-909 |
| Price | $335 |
| Order / More Info | CD172b (SIRPβ), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kharitonenkov, A. et al. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386 (6621): 181-186. | Dietrich, J. et al. (2000) Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. J Immunol 164 (1): 9-12. | Liu, Y. et al. (2005) SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. J. Biol. Chem. 280 (43): 36132-36140. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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