OSCAR, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | OSCAR, Human |
| Clone | REA494 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | OSCAR Antibody, anti-human, APC, REAfinity™. Clone REA494 recognizes the human osteoclast-associated immunoglobulin-like receptor (OSCAR) antigen, a 45 kDa single-pass type I membrane protein also known as polymeric immunoglobulin receptor 3 (PIgR-3). OSCAR is a member of the leukocyte receptor complex (LRC) protein family and is an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. OSCAR expression is detected in preosteoclasts or mature osteoclasts. Osteoclasts are terminally differentiated leukocytes that erode the mineralized bone matrix. These cells originate from hematopoietic precursors and share a common progenitor with macrophages and dendritic cells. Human OSCAR is also expressed at all stages of myeloid dendritic cell maturation, on in vitro derived macrophages, granulocytes, and monocyte derived dendritic cells. | Additional information: Clone REA494 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PIgR3, PIgR-3, hOSCAR |
| Gene, Accession # | Gene ID: 126014 |
| Catalog # | 130-119-672 |
| Price | $140 |
| Order / More Info | OSCAR, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Barrow, A. D. et al. (2011) OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest. 121 (9): 3505-3516. | Kim, N. et al. (2002) A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J. Exp. Med. 195 (2): 201-209. | Goettsch, C. et al. (2011) The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells. Endocrinology 152 (12): 4915-4926. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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