Edit |   |
---|---|
Antigenic Specificity | DCAR1, Mouse |
Clone | SKa5-3D5 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2b |
Format | phycoerythrin (PE) conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DCAR1 Antibody, anti-mouse, PE. Dendritic cell immunoactivating receptor 1 (DCAR1) belongs to a subfamily of cell surface C-type lectin receptors (CLR). Mouse DCAR1 shows a tissue specific expression pattern: it is expressed on CD8a+ DC subsets in spleen and thymus and on subsets of CD11b+ myeloid cells in bone marrow and spleen. Mouse DCAR1 has neither been detected in lymph nodes nor in peripheral blood. Antigen delivered via anti-DCAR1 antibody is internalized and is cycled through the early and late endosomal compartment, inducing cellular and humoral responses in vivo. Triggering DCAR1 via monoclonal antibody ligation on CD8+ DCs increases the secretion of bioactive IL-12 whereas secretion of IL-10 is markedly reduced, indicating that antigen recognized by mDCAR1 induces enhanced proinflammatory responses. Anti-DCAR1 antibodies have been tested on BALB/c and C57BL/6 mice. |
Immunogen | n/a |
Other Names | CLEC4b2, APLRA1 |
Gene, Accession # | Gene ID: 69810 |
Catalog # | 130-102-396 |
Price | $66 |
Order / More Info | DCAR1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | n/a |