TCR Vα3.2 (b, c), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCR Vα3.2 (b, c), Mouse |
| Clone | REA395 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCR Vα3.2 (b, c) Antibody, anti-mouse, APC-Vio® 770, REAfinity™. Clone REA395 recognizes the mouse Vα 3.2 T cell receptor (TCR Vα3.2) of mice having the b (e.g., C57BL/6) and c (e.g., SJL, NOD) haplotypes, but not with the strains having the a (Balb/c) or d (DBA/2) haplotype. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Vα elements are expressed preferentially in CD4 or CD8 subsets in a manner that is largely independent of the MHC haplotype. It is likely that the Vα elements interact preferentially with conserved regions of class I or class II molecules. | Additional information: Clone REA395 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TCRA, TCR Va3.2, TCR-Va3.2 |
| Gene, Accession # | Gene ID: 21473 |
| Catalog # | 130-106-056 |
| Price | $60 |
| Order / More Info | TCR Vα3.2 (b, c), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Sim, B. C. et al. (1997) V alpha 3.2 selection in MHC class I mutant mice: evidence for an alternate orientation of TCR-MHC class I interaction. J Immunol 159 (7): 3322-3329. | Pereira, P. et al. (1997) The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci. Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5761-5766. | von Essen, M. R. et al. (2012) Mechanisms behind functional avidity maturation in T cells. Clin. Dev. Immunol. 2012: 163453. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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