CD279 (PD1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD279 (PD1), Human
CloneREA1165
Host SpeciesRecombinant Human
Reactive Specieshuman, nonhuman primate
IsotypeIgG1
FormatVio R667 conjugate
Size600 µL
Concentration1:50
ApplicationsFlow cytometry
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DescriptionCD279 (PD1) Antibody, anti-human, Vio® R667, REAfinity™. Clone REA1165 recognizes the human CD279 antigen, also known as programmed death-1 (PD-1) or PD1. CD279 is a 55 kDa transmembran protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, activated myeloid cells, and dendritic cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (CD274, also knwon as B7-H1) and PD-L2 (CD273, also known as B7-DC) belong to the B7 immunglobulin superfamily. PD-1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. | Additional information: Clone REA1165 displays negligible binding to Fc receptors.
Immunogenn/a
Other NamesPDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Gene, Accession #Gene ID: 5133
Catalog #130-131-145
Price$666
Order / More InfoCD279 (PD1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesOkazaki, T. and Honjo, T. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol. 19: 813-824. | Keir, M. E. et al. (2008) PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677-704. | Serriari, N.-E. et al. (2010) B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function. J Immunol 185: 3140-3148. | Fife, B. T. et al. (2011) The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann. N. Y. Acad. Sci. 1217: 45-59.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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