CD88 (C5AR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD88 (C5AR), Human |
| Clone | REA1213 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright V423 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD88 (C5AR) Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA1213 recognizes the human CD88 antigen, a 43 kDa G type protein-coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 expression is originally described on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on astrocytes, microglia, and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist. | Additional information: Clone REA1213 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | C5AR1, C5A, C5AR, C5R1 |
| Gene, Accession # | Gene ID: 728 |
| Catalog # | 130-130-746 |
| Price | $208 |
| Order / More Info | CD88 (C5AR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gerard, N. P. et al. (1991) The chemotactic receptor for human C5a anaphylatoxin. Nature 349 (6310): 614-617. | Farzan, M. et al. (2001) Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J. Exp. Med. 193 (9): 1059-1066. | Buck, E. et al. (2005) Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 102: 2719-2724. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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