MEK1 pS298, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | MEK1 pS298, Human/Mouse |
| Clone | REA375 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MEK1 pS298 Antibody, anti-human/mouse, APC, REAfinity™. Clone REA375 recognizes the human and mouse MEK1 antigen phosphorylated at serine 298 (pS298). The dual specificity kinases MEK1 and MEK2 are activated by RAF and mediate phosphorylation of ERK1 and ERK2. MEK1 and MEK2 are very similar but differ structurally in a proline-rich domain in the C-terminal half of the catalytic core. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival, and differentiation, predominantly through the regulation of transcription, metabolism, and cytoskeletal rearrangements. MEK1 is phosphorylated at S298 by PAK. MAPK1/ERK2 phosphorylation of T292 occurs in response to cellular adhesion and leads to inhibition of S298 phosphorylation by PAK. | Additional information: Clone REA375 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MAP2K1, CFC3, MAPKK 1, MKK1, PRKMK1, MEK1 |
| Gene, Accession # | Gene ID: 5604 |
| Catalog # | 130-105-605 |
| Price | $142 |
| Order / More Info | MEK1 pS298, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Zheng, C. F. et al. (1994) Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J. 13 (5): 1123-1131. | Zheng, C. F. et al. (1993) Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268 (15): 11435-11439. | Coles, L. C. et al. (2002) PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway. Oncogene 21 (14): 2236-2244. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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