Ly-49E/F, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Ly-49E/F, Mouse |
| Clone | REA218 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ly-49E/F Antibody, anti-mouse, FITC, REAfinity™. Clone REA218 recognizes the mouse killer cell lectin-like receptor 5 and 6 (Ly-49E and Ly-49F) antigens, which are type II transmembrane natural killer cell receptors belonging to the Ly-49 family. Members of the Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands and include activating and inhibitory receptor molecules. Ly-49E is expressed abundantly on fetal or immature NK cells and on certain γδ T cells, but at barely detectable frequencies on adult splenic NK cells. Different from other Ly-49 receptors, Ly-49E contains an immunoreceptor tyrosine-based inhibitory motif domain, a charged transmembrane residue and it is present in all mouse strains. Its failure to bind to a variety of soluble or cell bound MHC class I molecules indicates that its natural ligand is not an endogenous class I molecule. IL-2 and IL-15 selectively induce the de novo expression of Ly-49E on the majority of mature NK cells. By contrast, IL-4 blocks this IL-2 induced acquisition of Ly-49E. Ly-49F is expressed on subsets of NK cells, NK-T cells, and on a subpopulation of memory T cells in C57BL/6 mice, but not AKR/J, BALB/c, C3H/HeN, DBA/1, or SJL mice. IL-21 selectively down-regulates Ly-49F on mature NK cells. | Additional information: Clone REA218 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | Klra5, Ly49e, Ly-49F, Klra6 |
| Gene, Accession # | Gene ID: 16636, 16637 |
| Catalog # | 130-102-696 |
| Price | $48 |
| Order / More Info | Ly-49E/F, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gays, F. et al. (2005) Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. J Immunol 175 (5): 2938-2947. | Smith, H. R. et al. (1994) Ly-49 multigene family expressed by IL-2-activated NK cells. J Immunol 153 (3): 1068-1079. | Van Beneden, K. et al. (2001) Expression of Ly49E and CD94/NKG2 on fetal and adult NK cells. J Immunol 166 (7): 4302-4311. | Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11 (1): 67-77. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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