F4/80, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | F4/80, Mouse |
| Clone | REA126 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 150 µg in 1 mL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | F4/80 Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA126 recognizes F4/80, a member of epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 is considered as one of the most specific cell-surface markers for murine macrophages. F4/80 is a seven-span transmembrane molecule with a large extracellular, multiple EGF module-containing domain. Constitutive and high expression of F4/80 is found on most resident tissue macrophages, including the spleen, microglia in the brain, Kupffer's cells in the liver, and Langerhans cells in the skin. In addition, the expression of F4/80 can also be regulated depending on the physiological status of the cell. F4/80 molecule is required for the differentiation of antigen-specific CD8+ Tregs and is involved in inducing peripheral immune tolerance. No specific ligand for F4/80 has been reported so far. | Additional information: Clone REA126 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | ADGRE1, DD7A5-7, EGF-TM7, EMR1, Gpf480, Ly71, TM7LN3 |
| Gene, Accession # | Gene ID: 13733 |
| Catalog # | 130-118-320 |
| Price | $450 |
| Order / More Info | F4/80, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lin, H.-H. et al. (2005) The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J. Exp. Med. 201: 1615-1625. | Gordon, S. et al. (2011) F4/80 and the related adhesion-GPCRs. Eur. J. Immunol. 41 (9): 2472-2476. | Kortlever, R. M. et al. (2017) Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. Cell 171 (6): 1301-1315. | Hume, D. A. et al. (1984) The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue. J. Cell. Sci. 66: 189-194. | Gu, C. et al. (2018) EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. PLoS Pathog. 14 (6): . | Siegmund, D. et al. (2016) Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis. Cell Death Dis 7 (9): e2375. | Siegmund, D. et al. (2018) TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling. Cell Death Dis 9 (9): . | Lee, H. et al. (2017) Kinetics of corneal antigen presenting cells in experimental dry eye disease. BMJ Open Ophthalmol 1 (1): . | Jia, J. et al. (2018) Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease. EMBO Mol. Med. 10 (5): . |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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