T-bet, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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|---|---|
| Antigenic Specificity | T-bet, Human/Mouse |
| Clone | REA102 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | T-bet Antibody, anti-human/mouse, APC, REAfinity™. The monoclonal antibody REA102 recognizes human and mouse T-bet, a T?1-specific T-box 1 transcription factor. T-bet is considered to be an important regulator of T?1 lymphoid development and is involved in class-switch recombination in B cells. It is widely expressed in hematopoietic cells such as B cells, T cell subsets, NK and NKT cells, and dendritic cells. Expression of T-bet is induced by T?1 cytokine IFN-γ and T-bet further regulates the expression of cytokines including IFN-γ, IL-12Rβ, and IL-2. | Additional information: Clone REA102 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TBX21, T-PET, TBLYM, TBT1, TBLYM |
| Gene, Accession # | Gene ID: 30009 |
| Catalog # | 130-119-821 |
| Price | $140 |
| Order / More Info | T-bet, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Szabo, S. J. et al. (2002) Distinct effects of T-bet in Th1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295: 338. | Lugo-Villarino, G. et al. (2003) T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 100: 7749-7754. | Peng, S. L. et al. (2002) T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl. Acad. Sci. U.S.A. 99: 5545-5550. | Szabo, S. J. et al. (2000) A novel transcription factor, T-bet, directs T?1 lineage commitment. Cell 100 (6): 655-669. | Qian, L. et al. (2014) Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes. PLoS One 9 (4): e96207. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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