CD16, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-CD16, Human antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | CD16, Human |
| Clone | REAL844 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD16 Antibody, anti-human, PE, REAdye_lease™. Clone REAL844 is an antibody fragment derived from the full CD16 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL844 recognizes the human CD16 antigen, a Single-pass type I membrane protein which is also known as Low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50-80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REAL844 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | FCGR3A, FCGR3B, FcR-10, IGRF3, IMD20, FcRIII |
| Gene, Accession # | n/a |
| Catalog # | 130-125-792 |
| Price | $410 |
| Order / More Info | CD16, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ravetch, J. V. et al. (1989) Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J. Exp. Med. 170 (2): 481-497. | Ziegler-Heitbrock, L. (2007) The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J. Leukoc. Biol. 584 (592): 584-592. | Romee, R. et al. (2013) NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17). Blood 121 (18): 3599-3608. | Romano, E. et al. (2015) Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. Proc. Natl. Acad. Sci. U.S.A. 112 (19): 6140-6145. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG
Return to Antibodies