Ly-49H, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Ly-49H, Mouse |
| Clone | REA241 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ly-49H Antibody, anti-mouse, APC, REAfinity™. Clone REA241 recognizes mouse lymphocyte antigen 49H (Ly-49H) which is also known as killer cell lectin-like receptor 8, Klra8, or Cmv-1. REA241 does not crossreact with related molecules like Ly-49A, C, D, or G2. Ly-49H is a member of the C-type lectin Ly-49 multigene family and is expressed by C57BL/6 and NWNA but not by BALB/c and DBA/2 mouse NK cells. It recognizes a ligand from mouse cytomegalovirus (MCMV), and engagement of Ly-49H can lead to killing of MCMV-infected cells. In addition to NK cell cytotoxicity, Ly-49H has a crucial role in supporting NK cell proliferation to prevent immunopathology caused by the adaptive immune system. | Additional information: Clone REA241 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | Klra8, Cmv-1, Cmv1, Cmv-1 |
| Gene, Accession # | Gene ID: 16639 |
| Catalog # | 130-103-344 |
| Price | $59 |
| Order / More Info | Ly-49H, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Smith, K. M. et al. (1989) Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J Immunol 161: 7-10. | Seung-Hwan, L. et al. (2003) Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J. Exp. Med. 197 (4): 515-526. | Seung-Hwan, L. et al. (2009) Activating receptors promote NK cell expansion for maintenance, IL10 production, and CD8 T cell regulation during viral infection. J. Exp. Med. 206: 2235-2251. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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