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Antigenic Specificity | CD107b, Human |
Clone | REA1073 |
Host Species | Recombinant Human |
Reactive Species | human, nonhuman primate |
Isotype | IgG1 |
Format | PE-Vio 770 conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Intracellular flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD107b Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA1073 recognizes the human CD107b, also known as lysosomal-associated membrane protein-2 (LAMP-2), which is a 120 kDa highly glycosylated type I transmembrane protein. It is widely located in lysosomal/endosomal membranes in a high variety of cell types and also expressed on degranulating T cells, activated platelets, and some tumor cell lines. CD107b is involved in cell adhesion and cellular homeostasis, including autophagocytosis and antigen presentation as well as in tumor cell metastasis. | Additional information: Clone REA1073 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | LAMP-2, LAMPB, LGP110 |
Gene, Accession # | Gene ID: 3920 |
Catalog # | 130-118-823 |
Price | $355 |
Order / More Info | CD107b, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Carlsson, S. R. et al. (1988) Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan. J. Biol. Chem. 263: 18911-18919. | Betts, M. R. et al. (2004) Detection of T-cell degranulation: CD107a and b. Method Cell Biol. 75: 497-512. | Grutzkau, A. et al. (2004) LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells. Cytometry A 61 (1): 62-68. |