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Antigenic Specificity | CD88 (C5AR), Mouse |
Clone | 20/70 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2bκ |
Format | PE-Vio 770 conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD88 (C5AR) Antibody, anti-mouse, PE-Vio® 770. Clone 20/70 recognizes the mouse CD88 antigen, a 43 kDa G type protein-coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 is expressed on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on microglia and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist. |
Immunogen | n/a |
Other Names | C5AR1, C5AR, C5R1, D7Msu1 |
Gene, Accession # | Gene ID: 12273 |
Catalog # | 130-106-125 |
Price | $167 |
Order / More Info | CD88 (C5AR), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Gerard, C. et al. (1992) Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol 149 (8): 2600-2606. | Sadik, C. D. et al. (2012) Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. Proc. Natl. Acad. Sci. U.S.A. 109 (46): E3177-E3185. | Bosmann, M. et al. (2013) The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur. J. Immunol. 43 (7): 1907-1913. |